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IMP5 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q8IUH8 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74503 Da |
| Gene ID | 162540 |
|---|---|
| Other Names | Signal peptide peptidase-like 2C, SPP-like 2C, SPPL2c, 3.4.23.-, Intramembrane protease 5, IMP-5, SPPL2C {ECO:0000303|PubMed:15385547} |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | SPPL2C (HGNC:28902) |
|---|---|
| Function | Sperm-specific intramembrane-cleaving aspartic protease (I- CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side |
| Tissue Location | Highly expressed in testis where it is primarily localised in spermatids (at protein level) |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP56335
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