IMP5 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q8IUH8 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 74503 Da |
Gene ID | 162540 |
---|---|
Other Names | Signal peptide peptidase-like 2C, SPP-like 2C, SPPL2c, 3.4.23.-, Intramembrane protease 5, IMP-5, SPPL2C {ECO:0000303|PubMed:15385547} |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | SPPL2C (HGNC:28902) |
---|---|
Function | Sperm-specific intramembrane-cleaving aspartic protease (I- CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side |
Tissue Location | Highly expressed in testis where it is primarily localised in spermatids (at protein level) |
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