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C14orf129 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9P0R6 |
| Other Accession | NM_016472, NP_057556 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Rabbit, Pig, Horse, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16kDa |
| Gene ID | 51527 |
|---|---|
| Alias Symbol | GSKIP, HSPC210, MGC4945, C14orf129 |
| Other Names | GSK3-beta interaction protein, GSKIP, GSKIP, C14orf129 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C14orf129 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | C14orf129 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSKIP {ECO:0000303|PubMed:16981698, ECO:0000312|HGNC:HGNC:20343} |
|---|---|
| Function | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:16981698, PubMed:25920809, PubMed:27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:16981698, PubMed:27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Chou H.-Y.,et al.Biochemistry 45:11379-11389(2006).
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