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> home > Products > Primary Antibodies > Cell Biology > HSPC210/GSK3beta interaction protein Polyclonal Antibody
HSPC210/GSK3beta interaction protein Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q9P0R6 |
| Reactivity | Rat, Cynomolgus Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15648 Da |
| Gene ID | 51527 |
|---|---|
| Other Names | GSK3B-interacting protein {ECO:0000312|HGNC:HGNC:20343}, GSKIP, GSK3beta interaction protein {ECO:0000312|HGNC:HGNC:20343}, GSKIP {ECO:0000303|PubMed:16981698, ECO:0000312|HGNC:HGNC:20343} |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | GSKIP {ECO:0000303|PubMed:16981698, ECO:0000312|HGNC:HGNC:20343} |
|---|---|
| Function | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas |
Research Areas
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Application Protocols
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$ 350.00
Cat# AP56946
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