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MFN1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8R4Z9 |
| Other Accession | NM_033540, NP_284941 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84 KDa |
| Gene ID | 192647 |
|---|---|
| Alias Symbol | DKFZp762F247, FLJ20693, MGC41806, hfzo1, hfzo2 |
| Other Names | Mitofusin-1, 3.6.5.-, Mitochondrial transmembrane GTPase FZO1B, Transmembrane GTPase MFN1, Mfn1, Fzo1b |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MFN1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MFN1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Mfn1 |
|---|---|
| Synonyms | Fzo1b |
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:14561718, PubMed:12589796). Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains (By similarity). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:14561718). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:14561718). Has low GTPase activity (By similarity). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. In brain, it is expressed at weaker level than MFN2, while it is expressed at a higher level than MFN2 in heart and testis. Expressed at high level in elongating spermatids of seminiferous tubules. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Eura Y.,et al.J. Biochem. 134:333-344(2003).
Ishihara N.,et al.Biochem. Biophys. Res. Commun. 301:891-898(2003).
Honda S.,et al.Biochem. Biophys. Res. Commun. 311:424-432(2003).
Eura Y.,et al.J. Cell Sci. 119:4913-4925(2006).
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