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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Tfam antibody - middle region   

Tfam antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Tfam antibody - middle region AI14321

    WB Suggested Anti-Tfam Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:1562500
    Positive Control: Mouse Muscle
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P40630
Other Accession NM_009360, NP_033386
Reactivity Mouse
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 28kDa
Additional Information
Gene ID 21780
Alias Symbol AI661103, Hmgts, mtTFA, tsHMG
Other Names Transcription factor A, mitochondrial, mtTFA, Testis-specific high mobility group protein, TS-HMG, Tfam, Hmgts
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Tfam antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTfam antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tfam {ECO:0000312|MGI:MGI:107810}
Synonyms Hmgts
Function [Isoform Mitochondrial]: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (By similarity). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (By similarity). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (By similarity). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (By similarity). Is able to unwind DNA (By similarity). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (By similarity). Required for maintenance of normal levels of mitochondrial DNA (PubMed:9500544). May play a role in organizing and compacting mitochondrial DNA (PubMed:17581862).
Cellular Location [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:Q00059}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q00059}
Tissue Location The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific
Research Areas
Citations (0)

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Larsson N.G.,et al.Nat. Genet. 13:296-302(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Cermakian N.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Boissonneault G.,et al.Mol. Cell. Biol. 13:4323-4330(1993).
Larsson N.G.,et al.Nat. Genet. 18:231-236(1998).

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$ 389.00
Cat# AI14321
Availability: 2-3 days
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