|Other Accession||NM_018750, NP_061220|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||1300019G20Rik, AU042887, Maxp1, Nore1, Nore1A, Nore1B, Rapl|
|Other Names||Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, Rassf5, Nore1, Rapl|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Rassf5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Rassf5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Vavvas D.,et al.J. Biol. Chem. 273:5439-5442(1998).
Katagiri K.,et al.Nat. Immunol. 4:741-748(2003).
Okazaki N.,et al.DNA Res. 11:127-135(2004).
Carninci P.,et al.Science 309:1559-1563(2005).
Khokhlatchev A.,et al.Curr. Biol. 12:253-265(2002).
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