Rassf5 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q5EBH1 |
Other Accession | NM_018750, NP_061220 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47kDa |
Gene ID | 54354 |
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Alias Symbol | 1300019G20Rik, AU042887, Maxp1, Nore1, Nore1A, Nore1B, Rapl |
Other Names | Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, Rassf5, Nore1, Rapl |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Rassf5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Rassf5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Rassf5 |
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Synonyms | Nore1, Rapl |
Function | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
References
Vavvas D.,et al.J. Biol. Chem. 273:5439-5442(1998).
Katagiri K.,et al.Nat. Immunol. 4:741-748(2003).
Okazaki N.,et al.DNA Res. 11:127-135(2004).
Carninci P.,et al.Science 309:1559-1563(2005).
Khokhlatchev A.,et al.Curr. Biol. 12:253-265(2002).
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