|Other Accession||NM_032855, NP_116244|
|Alias Symbol||ALX, FLJ14886, HSH2|
|Other Names||Hematopoietic SH2 domain-containing protein, Hematopoietic SH2 protein, Adaptor in lymphocytes of unknown function X, HSH2D, ALX|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HSH2D antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HSH2D antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Oda T.,et al.Biochem. Biophys. Res. Commun. 288:1078-1086(2001).
Greene T.A.,et al.J. Biol. Chem. 278:45128-45134(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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