|Other Accession||NM_001207006, NP_001193935|
|Reactivity||Human, Pig, Goat, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Pig, Goat, Sheep, Horse, Bovine, Dog|
|Alias Symbol||IL-21, Za11|
|Other Names||Interleukin-21, IL-21, Za11, IL21|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-IL21 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||IL21 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).|
|Tissue Location||Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes|
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