|Other Accession||NM_005989, NP_005980|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Bovine, Dog|
|Alias Symbol||3o5bred, CBAS2, SRD5B1|
|Other Names||3-oxo-5-beta-steroid 4-dehydrogenase, 126.96.36.199, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-AKR1D1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||AKR1D1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one).|
|Tissue Location||Highly expressed in liver. Expressed in testis and weakly in colon.|
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Provided below are standard protocols that you may find useful for product applications.
Kondo K.-H.,et al.Eur. J. Biochem. 219:357-363(1994).
Charbonneau A.,et al.Biochim. Biophys. Acta 1517:228-235(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
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