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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Nploc4 Antibody - N-terminal region   

Nploc4 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Nploc4 Antibody - N-terminal region AI14808

    Host: Rabbit
    Target Name: Nploc4
    Sample Tissue: Mouse Testis lysates
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P60670
Other Accession NM_001195023, NP_001181952
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 66kDa
Additional Information
Gene ID 217365
Alias Symbol AK129375, Npl4, mKIAA1499
Other Names Nuclear protein localization protein 4 homolog, Protein NPL4, Nploc4, Kiaa1499, Npl4
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Nploc4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNploc4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Nploc4
Synonyms Kiaa1499, Npl4
Function The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES54}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES54}. Nucleus {ECO:0000250|UniProtKB:Q9ES54} Note=Associated with the endoplasmic reticulum and nuclear {ECO:0000250|UniProtKB:Q9ES54}
Research Areas
Citations (0)

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References

Okazaki N.,et al.DNA Res. 10:167-180(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Park J.,et al.Mol. Cell 50:919-930(2013).

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$ 389.00
Cat# AI14808
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