|Other Accession||NM_002386, NP_002377|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig|
|Predicted||Human, Mouse, Rat, Rabbit, Pig|
|Alias Symbol||CMM5, MGC14337, MSH-R, SHEP2|
|Other Names||Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-MC1R antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MC1R Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670, PubMed:8463333, PubMed:1516719, PubMed:11442765, PubMed:11707265). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670, PubMed:11707265, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in melanocytes (PubMed:1325670, PubMed:31097585). Expressed in corticoadrenal tissue (PubMed:1325670)|
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Provided below are standard protocols that you may find useful for product applications.
Mountjoy K.G.,et al.Science 257:1248-1251(1992).
Gantz I.,et al.J. Biol. Chem. 268:8246-8250(1993).
Chhajlani V.,et al.FEBS Lett. 309:417-420(1992).
Chhajlani V.,et al.FEBS Lett. 390:238-238(1996).
Rana B.K.,et al.Genetics 151:1547-1557(1999).
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