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MC1R Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q01726 |
| Other Accession | NM_002386, NP_002377 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig |
| Predicted | Human, Mouse, Rat, Rabbit, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35kDa |
| Gene ID | 4157 |
|---|---|
| Alias Symbol | CMM5, MGC14337, MSH-R, SHEP2 |
| Other Names | Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MC1R antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MC1R Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MC1R |
|---|---|
| Synonyms | MSHR |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in melanocytes (PubMed:1325670, PubMed:31097585). Expressed in corticoadrenal tissue (PubMed:1325670) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Mountjoy K.G.,et al.Science 257:1248-1251(1992).
Gantz I.,et al.J. Biol. Chem. 268:8246-8250(1993).
Chhajlani V.,et al.FEBS Lett. 309:417-420(1992).
Chhajlani V.,et al.FEBS Lett. 390:238-238(1996).
Rana B.K.,et al.Genetics 151:1547-1557(1999).
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