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NRTN antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q99748 |
| Other Accession | NM_004558, NP_004549 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Bovine, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 22kDa |
| Gene ID | 4902 |
|---|---|
| Alias Symbol | NTN |
| Other Names | Neurturin, NRTN |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-NRTN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NRTN antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRTN {ECO:0000303|PubMed:31535977, ECO:0000312|HGNC:HGNC:8007} |
|---|---|
| Function | Growth factor that supports the survival of sympathetic neurons in culture (PubMed:8945474). May regulate the development and maintenance of the CNS (PubMed:8945474). Involved in the development of the neural crest (PubMed:15242795). Might control the size of non- neuronal cell population such as haemopoietic cells (PubMed:8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:29414779, PubMed:31535977). Heparan sulfate- binding is required for signaling (PubMed:29414779). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P97463}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Kotzbauer P.T.,et al.Nature 384:467-470(1996).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Doray B.,et al.Hum. Mol. Genet. 7:1449-1452(1998).
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