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NRTN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99748 |
| Other Accession | NP_004549.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22405 Da |
| Antigen Region | 46-75 aa |
| Gene ID | 4902 |
|---|---|
| Other Names | Neurturin, NRTN |
| Target/Specificity | This NRTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human NRTN. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NRTN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRTN {ECO:0000303|PubMed:31535977, ECO:0000312|HGNC:HGNC:8007} |
|---|---|
| Function | Growth factor that supports the survival of sympathetic neurons in culture (PubMed:8945474). May regulate the development and maintenance of the CNS (PubMed:8945474). Involved in the development of the neural crest (PubMed:15242795). Might control the size of non- neuronal cell population such as haemopoietic cells (PubMed:8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:29414779, PubMed:31535977). Heparan sulfate- binding is required for signaling (PubMed:29414779). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P97463}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq].
References
Fernandez, R.M., et al. J. Pediatr. Surg. 43(11):2042-2047(2008)
Adly, M.A., et al. J. Am. Acad. Dermatol. 58(2):238-250(2008)
Yoong, L.F., et al. J. Neurosci. 27(21):5603-5614(2007)
Yoong, L.F., et al. J. Neurochem. 98(4):1149-1158(2006)
Vargas-Leal, V., et al. J. Immunol. 175(4):2301-2308(2005)
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