|Other Accession||NM_172139, NP_742151|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Dog|
|Predicted||Human, Mouse, Rat|
|Alias Symbol||IFNL3, IL-28B, IL28C, IL28B|
|Other Names||Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, IFNL3, IL28B, IL28C, ZCYTO22|
|Target/Specificity||This antibody is pan-IL28 specific, as there is 100% homology to the human IL28A sequence, per http://www.uniprot.org/uniprot/Q8IZJ0.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-IL28B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||IL28B antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IL28B, IL28C, ZCYTO22|
|Function||Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Sheppard P.,et al.Nat. Immunol. 4:63-68(2003).
Kotenko S.V.,et al.Nat. Immunol. 4:69-77(2003).
Li M.C.,et al.Acta Pharmacol. Sin. 27:453-459(2006).
Grimwood J.,et al.Nature 428:529-535(2004).
Donnelly R.P.,et al.J. Interferon Cytokine Res. 30:555-564(2010).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.