COQ7 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application ![]()
| WB |
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Primary Accession | Q99807 |
Other Accession | NM_001190983, NP_001177912 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 20kDa |
Gene ID | 10229 |
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Alias Symbol | CAT5, CLK-1, CLK1 |
Other Names | Ubiquinone biosynthesis protein COQ7 homolog, Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog, COQ7 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-COQ7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | COQ7 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | COQ7 {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000312|HGNC:HGNC:2244} |
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Function | Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all- trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (Probable). Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers (PubMed:23445365). The binding of 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation (PubMed:23445365). The physiological substrates are 5-methoxy-2-methyl-3-(all-trans- nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans- decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency (PubMed:23445365, PubMed:28409910). Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (PubMed:25961505). |
Cellular Location | Mitochondrion inner membrane {ECO:0000255|HAMAP- Rule:MF_03194}; Peripheral membrane protein {ECO:0000255|HAMAP- Rule:MF_03194}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194} Mitochondrion. Nucleus. Chromosome |
Tissue Location | Expressed dominantly in heart and skeletal muscle. |

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Provided below are standard protocols that you may find useful for product applications.
References
Asaumi S.,et al.Genomics 58:293-301(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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