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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > COQ7 Antibody (C-term)
COQ7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | Q99807 |
| Other Accession | NP_057222.2, NP_001177912.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24277 Da |
| Antigen Region | 162-191 aa |
| Gene ID | 10229 |
|---|---|
| Other Names | Ubiquinone biosynthesis protein COQ7 homolog, Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog, COQ7 |
| Target/Specificity | This COQ7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the C-terminal region of human COQ7. |
| Dilution | IHC-P~~1:50~100 FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COQ7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COQ7 {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000312|HGNC:HGNC:2244} |
|---|---|
| Function | Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all- trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (Probable). Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers (PubMed:23445365). The binding of 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation (PubMed:23445365). The physiological substrates are 5-methoxy-2-methyl-3-(all-trans- nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans- decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency (PubMed:23445365, PubMed:28409910). Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (PubMed:25961505). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000255|HAMAP- Rule:MF_03194}; Peripheral membrane protein {ECO:0000255|HAMAP- Rule:MF_03194}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194} Mitochondrion. Nucleus. Chromosome |
| Tissue Location | Expressed dominantly in heart and skeletal muscle. |
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$ 150.00
$ 385.00
Cat# AP5880b
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