|Other Accession||NM_152288, NP_689501|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||MGC13024, TMEM142C|
|Other Names||Protein orai-3, Transmembrane protein 142C, ORAI3, TMEM142C|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ORAI3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ORAI3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in both naive and effector T helper cells with higher levels in effector cells.|
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Feske S.,et al.Nature 441:179-185(2006).
Srikanth S.,et al.Nat. Cell Biol. 12:436-446(2010).
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