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> home > Products > Primary Antibodies > Antibody Collections > Inflammasome > NLRX1 Antibody - C-terminal region
NLRX1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q86UT6 |
| Other Accession | NM_024618, NP_078894 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 107kDa |
| Gene ID | 79671 |
|---|---|
| Alias Symbol | CLR11.3, DLNB26, FLJ21478, MGC131937, MGC21025, NOD26, NOD5, NOD9 |
| Other Names | NLR family member X1, Caterpiller protein 11.3, CLR11.3, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, Nucleotide-binding oligomerization domain protein 9, NLRX1, NOD26, NOD5, NOD9 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-NLRX1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NLRX1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NLRX1 |
|---|---|
| Function | Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity). |
| Cellular Location | Mitochondrion outer membrane |
| Tissue Location | Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL- 60, Raji and Jurkat cell lines (at protein level) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Inohara N.,et al.Nat. Rev. Immunol. 3:371-382(2003).
Kronos K.,et al.Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
Kubo T.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Inohara N.,et al.Annu. Rev. Biochem. 74:355-383(2005).
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$ 389.00
Cat# AI15201
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