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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   RTN4RL2 Antibody - C-terminal region   

RTN4RL2 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - RTN4RL2 Antibody - C-terminal region AI15349

    WB Suggested Anti-RTN4RL2 Antibody Titration: 1.0 μg/ml
    Positive Control: A549 Whole Cell
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q86UN3
Other Accession NM_178570, NP_848665
Reactivity Human, Mouse, Rat, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Additional Information
Gene ID 349667
Alias Symbol NGRH1, NgR2
Other Names Reticulon-4 receptor-like 2, Nogo receptor-like 3, Nogo-66 receptor homolog 1, Nogo-66 receptor-related protein 2, NgR2, RTN4RL2 (HGNC:23053)
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-RTN4RL2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRTN4RL2 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RTN4RL2 (HGNC:23053)
Function Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7M6Z0}. Perikaryon {ECO:0000250|UniProtKB:Q80WD1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WD1}. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000250|UniProtKB:Q7M6Z0}
Tissue Location Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
Research Areas
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References

Pignot V.,et al.J. Neurochem. 85:717-728(2003).
Lauren J.,et al.Mol. Cell. Neurosci. 24:581-594(2003).
Rader C.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
Barton W.A.,et al.EMBO J. 22:3291-3302(2003).

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$ 389.00
Cat# AI15349
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