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DAND5 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8N907 |
| Other Accession | NM_152654, NP_689867 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21kDa |
| Gene ID | 199699 |
|---|---|
| Alias Symbol | CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, MGC126849, SP1 |
| Other Names | DAN domain family member 5, Cerberus-like protein 2, Cerl-2, Cysteine knot superfamily 1, BMP antagonist 3, Gremlin-3, DAND5, CER2, CKTSF1B3, GREM3, SP1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DAND5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | DAND5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DAND5 |
|---|---|
| Function | Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance (PubMed:33587337). |
| Cellular Location | Secreted. Note=Circulating DAND5 may be uptaken by endothelial cells and transported to mitochondria |
| Tissue Location | Expressed in the retina, in inner segments of photoreceptors, at or close to the outer plexiform layer and in the ganglion cell layer (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Itoh N.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Katoh M.,et al.Oncol. Rep. 12:423-427(2004).
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