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MEPCE Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - MEPCE Antibody - middle region AI15441

    Host: Rabbit
    Target Name: MEPCE
    Sample Tissue: NCI-H226 Whole cell lysate
    s
    Antibody Dilution: 1.0μg/mlMEPCE is supported by BioGPS gene expression data to be expressed in NCIH226
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q7L2J0
Other Accession NM_019606, NP_062552
Reactivity Human, Rat, Rabbit, Guinea Pig, Dog
Predicted Human, Rat, Rabbit, Pig, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 76kDa
Additional Information
Gene ID 56257
Alias Symbol BCDIN3, FLJ20257
Other Names 7SK snRNA methylphosphate capping enzyme, MePCE, 2.1.1.-, Bicoid-interacting protein 3 homolog, Bin3 homolog, MEPCE, BCDIN3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-MEPCE antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMEPCE Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEPCE {ECO:0000303|PubMed:30559425, ECO:0000312|HGNC:HGNC:20247}
Function S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723).
Cellular Location Nucleus.
Tissue Location Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis (PubMed:12358911). Weakly or not expressed in other tissues (PubMed:12358911).
Research Areas
Citations (0)
citation

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References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Rogers S.A.,et al.Br. J. Haematol. 119:112-114(2002).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).

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$ 389.00
Cat# AI15441
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