|Other Accession||NM_025130, NP_079406|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Other Names||Putative hexokinase HKDC1, 18.104.22.168, Hexokinase domain-containing protein 1, HKDC1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HKDC1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HKDC1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the phosphorylation of hexose to hexose 6- phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity).|
|Cellular Location||Mitochondrion membrane; Peripheral membrane protein. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion|
|Tissue Location||Widely expressed (PubMed:27459389, PubMed:29401404). Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level) (PubMed:29401404) Present at moderate level in the thyroid follicular epithelium (at protein level) (PubMed:29401404).|
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Provided below are standard protocols that you may find useful for product applications.
Deloukas P.,et al.Nature 429:375-381(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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