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GFRAL Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6UXV0 |
| Other Accession | NM_207410, NP_997293 |
| Reactivity | Human, Rabbit, Pig, Bovine |
| Predicted | Human, Rabbit, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Gene ID | 389400 |
|---|---|
| Alias Symbol | C6orf144, GRAL, UNQ9356, bA360D14.1 |
| Other Names | GDNF family receptor alpha-like, GFRAL, C6orf144 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GFRAL antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GFRAL Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GFRAL (HGNC:32789) |
|---|---|
| Synonyms | C6orf144 |
| Function | Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. |
| Cellular Location | Cell membrane; Single-pass membrane protein; Extracellular side |
| Tissue Location | Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).
Sjoeblom T.,et al.Science 314:268-274(2006).
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