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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   GFRAL Antibody - N-terminal region   

GFRAL Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - GFRAL Antibody - N-terminal region AI15616

    Host: Rabbit
    Target Name: GFRAL
    Sample Tissue: Hela Whole cell lysate
    s
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q6UXV0
Other Accession NM_207410, NP_997293
Reactivity Human, Rabbit, Pig, Bovine
Predicted Human, Rabbit, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Additional Information
Gene ID 389400
Alias Symbol C6orf144, GRAL, UNQ9356, bA360D14.1
Other Names GDNF family receptor alpha-like, GFRAL, C6orf144
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-GFRAL antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGFRAL Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GFRAL (HGNC:32789)
Synonyms C6orf144
Function Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Cellular Location Cell membrane; Single-pass membrane protein; Extracellular side
Tissue Location Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097).
Research Areas
Citations (0)

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References

Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).
Sjoeblom T.,et al.Science 314:268-274(2006).

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$ 389.00
Cat# AI15616
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