|Other Accession||NM_207410, NP_997293|
|Reactivity||Human, Rabbit, Pig, Bovine|
|Predicted||Human, Rabbit, Pig, Bovine|
|Alias Symbol||C6orf144, GRAL, UNQ9356, bA360D14.1|
|Other Names||GDNF family receptor alpha-like, GFRAL, C6orf144|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GFRAL antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GFRAL Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.|
|Cellular Location||Cell membrane; Single-pass membrane protein; Extracellular side|
|Tissue Location||Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097).|
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Provided below are standard protocols that you may find useful for product applications.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).
Sjoeblom T.,et al.Science 314:268-274(2006).
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