GFRAL Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, FC, E |
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Primary Accession | Q6UXV0 |
Other Accession | NP_997293.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44518 Da |
Antigen Region | 366-394 aa |
Gene ID | 389400 |
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Other Names | GDNF family receptor alpha-like, GFRAL, C6orf144 |
Target/Specificity | This GFRAL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-394 amino acids from the C-terminal region of human GFRAL. |
Dilution | WB~~1:2000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GFRAL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GFRAL (HGNC:32789) |
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Synonyms | C6orf144 |
Function | Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. |
Cellular Location | Cell membrane; Single-pass membrane protein; Extracellular side |
Tissue Location | Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097). |
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Provided below are standard protocols that you may find useful for product applications.
References
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :
Li, Z., et al. J. Neurochem. 95(2):361-376(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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