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RRP8 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O43159 |
| Other Accession | NM_015324, NP_056139 |
| Reactivity | Human, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Predicted | Human, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50kDa |
| Gene ID | 23378 |
|---|---|
| Alias Symbol | KIAA0409 |
| Other Names | Ribosomal RNA-processing protein 8, 2.1.1.-, Cerebral protein 1, Nucleomethylin, RRP8, KIAA0409, NML |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RRP8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RRP8 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RRP8 |
|---|---|
| Synonyms | KIAA0409, NML |
| Function | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
| Cellular Location | Nucleus, nucleolus Note=Localizes at rDNA locus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Yazaki M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Andersen J.S.,et al.Curr. Biol. 12:1-11(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
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