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Anti-RRP8 Antibody
Rabbit polyclonal antibody to RRP8
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Application 
| WB, IHC |
|---|---|
| Primary Accession | O43159 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50715 Da |
| Gene ID | 23378 |
|---|---|
| Other Names | KIAA0409; NML; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin |
| Target/Specificity | Recognizes endogenous levels of RRP8 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | RRP8 |
|---|---|
| Synonyms | KIAA0409, NML |
| Function | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
| Cellular Location | Nucleus, nucleolus Note=Localizes at rDNA locus |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RRP8. The exact sequence is proprietary.
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