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DRAXIN Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8NBI3 |
| Other Accession | NM_198545NP_940947 |
| Reactivity | Human, Pig, Horse, Bovine, Dog |
| Predicted | Human, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36kDa |
| Gene ID | 374946 |
|---|---|
| Alias Symbol | AGPA3119, UNQ3119, neucrin |
| Other Names | Draxin {ECO:0000255|HAMAP-Rule:MF_03060}, Dorsal inhibitory axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060}, Dorsal repulsive axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060}, Neucrin, DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060}, C1orf187 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DRAXIN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | DRAXIN Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060} |
|---|---|
| Synonyms | C1orf187 |
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
References
Miyake A.,et al.Biochem. Biophys. Res. Commun. 390:1051-1055(2009).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Gregory S.G.,et al.Nature 441:315-321(2006).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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