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SHISA7 Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - SHISA7 Antibody - middle region AI16005

    Host: Rabbit
    Target Name: SHISA7
    Sample Tissue: OVCAR-3 Whole cell lysate
    s
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession A6NL88
Other Accession NM_001145176, NP_001138648
Reactivity Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 59kDa
Additional Information
Gene ID 729956
Other Names Protein shisa-7, Protein shisa-6-like, SHISA7
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-SHISA7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSHISA7 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHISA7 (HGNC:35409)
Function Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses.
Cellular Location Cell junction, synapse, postsynaptic density membrane {ECO:0000250|UniProtKB:Q8C3Q5}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8C3Q5}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. {ECO:0000250|UniProtKB:Q8C3Q5}
Research Areas
Citations (0)

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References

Grimwood J.,et al.Nature 428:529-535(2004).
Stevens M.,et al.Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI16005
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