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SHISA7 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | A6NL88 |
| Reactivity | Rat, Dog, Cow |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56214 Da |
| Gene ID | 729956 |
|---|---|
| Other Names | Protein shisa-7, Cystine-knot AMPAR modulating protein of 59 kDa, CKAMP59, GABA(A) receptor auxiliary subunit Shisa7, Protein shisa-6-like, SHISA7 (HGNC:35409) |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | SHISA7 (HGNC:35409) |
|---|---|
| Function | Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. |
| Cellular Location | Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8C3Q5}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8C3Q5}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons {ECO:0000250|UniProtKB:Q8C3Q5} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP56704
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