|Other Names||Cyclin-dependent kinase 10, 126.96.36.199, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE, CDK10|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-CDK10 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CDK10 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).|
|Cellular Location||Cytoplasm, cytoskeleton, cilium basal body|
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Provided below are standard protocols that you may find useful for product applications.
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).
Grana X.,et al.Oncogene 9:2097-2103(1994).
Grana X.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Brambilla R.,et al.Oncogene 9:3037-3041(1994).
Crawford J.,et al.Genomics 56:90-97(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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