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SMARCAL1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NZC9 |
| Other Accession | XP_005246689 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 104kDa |
| Gene ID | 50485 |
|---|---|
| Alias Symbol | SMARCAL1, HARP, |
| Other Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, 3.6.4.-, HepA-related protein, hHARP, Sucrose nonfermenting protein 2-like 1, SMARCAL1, HARP |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-SMARCAL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SMARCAL1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMARCAL1 (HGNC:11102) |
|---|---|
| Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. |
| Cellular Location | Nucleus Note=Recruited to damaged DNA regions |
| Tissue Location | Ubiquitously expressed, with high levels in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.
References
Coleman M.A.,et al.Genomics 65:274-282(2000).
Boerkoel C.F.,et al.Nat. Genet. 30:215-220(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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