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STAMBPL1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q96FJ0 |
| Reactivity | Human, Rat, Rabbit, Pig, Horse, Guinea Pig |
| Predicted | Human, Rat, Rabbit, Pig, Horse, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47kDa |
| Gene ID | 57559 |
|---|---|
| Alias Symbol | STAMBPL1, AMSHLP, KIAA1373, |
| Other Names | AMSH-like protease, AMSH-LP, 3.4.19.-, STAM-binding protein-like 1, STAMBPL1, AMSHLP, KIAA1373 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-STAMBPL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | STAMBPL1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STAMBPL1 {ECO:0000303|PubMed:35114100, ECO:0000312|HGNC:HGNC:24105} |
|---|---|
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys- 63'-linked deubiquitination of SESN2, thereby inhibiting SESN2- interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
References
Kikuchi K.,et al.Biochem. Biophys. Res. Commun. 306:637-643(2003).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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