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STAMBPL1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q96FJ0 |
| Other Accession | NP_065850.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49783 Da |
| Antigen Region | 135-163 aa |
| Gene ID | 57559 |
|---|---|
| Other Names | AMSH-like protease, AMSH-LP, 3419-, STAM-binding protein-like 1, STAMBPL1, AMSHLP, KIAA1373 |
| Target/Specificity | This STAMBPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-163 amino acids from the Central region of human STAMBPL1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STAMBPL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STAMBPL1 {ECO:0000303|PubMed:35114100, ECO:0000312|HGNC:HGNC:24105} |
|---|---|
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys- 63'-linked deubiquitination of SESN2, thereby inhibiting SESN2- interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
STAMBPL1 is zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
References
Reyes-Ibarra, A.P., et al. Mol. Endocrinol. 21(6):1394-1407(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Nakamura, M., et al. Genes Cells 11(6):593-606(2006)
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