|Other Accession||NM_003841, NP_003832|
|Alias Symbol||CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID, TRAIL-R3, DCR1-TNFR|
|Other Names||Tumor necrosis factor receptor superfamily member 10C, Antagonist decoy receptor for TRAIL/Apo-2L, Decoy TRAIL receptor without death domain, Decoy receptor 1, DcR1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL-R3, TRAIL receptor without an intracellular domain, CD263, TNFRSF10C, DCR1, LIT, TRAILR3, TRID|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TNFRSF10C antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TNFRSF10C antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCR1, LIT, TRAILR3, TRID|
|Function||Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL- R1 and R2 for binding to the ligand.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).
Degli-Esposti M.A.,et al.J. Exp. Med. 186:1165-1170(1997).
Pan G.,et al.Science 277:815-818(1997).
Sheridan J.P.,et al.Science 277:818-821(1997).
Schneider P.,et al.FEBS Lett. 416:329-334(1997).
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