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GPR35 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GPR35 Antibody (C-Terminus) ALS10000
    Anti-GPR35 antibody ALS10000 IHC of human pancreas.
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  • IHC - GPR35 Antibody (C-Terminus) ALS10000
    Anti-GPR35 antibody IHC of human Ovary, Carcinoma.
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  • IHC - GPR35 Antibody (C-Terminus) ALS10000
    Anti-GPR35 antibody IHC of human Pancreas, Carcinoma.
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  • IHC - GPR35 Antibody (C-Terminus) ALS10000
    Anti-GPR35 antibody IHC of human Skin, Melanoma.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC
Primary Accession Q9HC97
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Dilution IHC-P (12-23 µg/ml)
Additional Information
Gene ID 2859
Other Names G-protein coupled receptor 35, Kynurenic acid receptor, KYNA receptor, GPR35
Target/Specificity Human GPR35. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR35 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR35
Function G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:16754668, PubMed:20361937, PubMed:35148838). Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand (PubMed:35148838). Stimulates lipid metabolism, thermogenic, and anti- inflammatory gene expression in adipose tissue once activated by kynurenic acid (By similarity). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid
Tissue Location Predominantly expressed in immune and gastrointestinal tissues.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

References

O'Dowd B.F.,et al.Genomics 47:310-313(1998).
Horikawa Y.,et al.Nat. Genet. 26:163-175(2000).
Warren C.N.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS10000
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