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HTR6 / 5-HT6 Receptor Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P50406 |
| Reactivity | Human, Hamster, Monkey, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47kDa |
| Dilution | IHC-P (10-20 µg/ml) |
| Gene ID | 3362 |
|---|---|
| Other Names | 5-hydroxytryptamine receptor 6, 5-HT-6, 5-HT6, Serotonin receptor 6, HTR6 |
| Target/Specificity | Human HTR6 / 5-HT36. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | HTR6 / 5-HT6 Receptor Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTR6 (HGNC:5301) |
|---|---|
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614). HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614, PubMed:37327704). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (PubMed:23027611). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in several human brain regions, most prominently in the caudate nucleus. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
References
Kohen R.,et al.J. Neurochem. 66:47-56(1996).
Kopatz S.A.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ullmer C.,et al.FEBS Lett. 370:215-221(1995).
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