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HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q13639 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44kDa |
| Dilution | IHC-P (5-10 µg/ml) |
| Gene ID | 3360 |
|---|---|
| Other Names | 5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4 |
| Target/Specificity | Human 5HT4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTR4 |
|---|---|
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli |
| Tissue Location | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
References
Blondel O.,et al.J. Neurochem. 70:2252-2261(1998).
Van den Wyngaert I.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.NeuroReport 8:3189-3195(1997).
Syversveen T.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.Mol. Pharmacol. 55:910-920(1999).
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