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HTR4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13639 |
| Other Accession | NP_001035259.1, NP_000861.1, NP_955525.1, NP_001035262.2 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43761 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 3360 |
|---|---|
| Other Names | 5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4 |
| Target/Specificity | This HTR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HTR4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HTR4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTR4 |
|---|---|
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli |
| Tissue Location | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
References
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010) Maillet, M., et al. Biochem. J. 387 (PT 2), 463-471 (2005) : Brattelid, T., et al. Naunyn Schmiedebergs Arch. Pharmacol. 369(6):616-628(2004) Hiroi, T., et al. Biochem. Biophys. Res. Commun. 289(2):337-344(2001) Bender, E., et al. J. Neurochem. 74(2):478-489(2000)
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