|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Rabbit, Monkey, Pig, Horse|
|Dilution||IHC-P (5-12 µg/ml)|
|Other Names||Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein, GPR137B, TM7SF1|
|Target/Specificity||Human GPR137B / TM7SF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR137B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein. Note=Colocalized with MTOR in lysosome after amino acid stimulation.|
|Tissue Location||Expressed in kidney, heart, brain and placenta.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Spangenberg C.,et al.Genomics 48:178-185(1998).
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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