GPR137B Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | O60478 |
Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Dilution | IHC-P (5-13 µg/ml) |
Gene ID | 7107 |
---|---|
Other Names | Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein, GPR137B, TM7SF1 |
Target/Specificity | Human GPR137B / TM7SF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR137C (44%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | GPR137B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPR137B |
---|---|
Synonyms | TM7SF1 {ECO:0000303|PubMed:22729905} |
Function | Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). |
Cellular Location | Lysosome membrane; Multi-pass membrane protein. Note=Colocalized with MTOR in lysosome after amino acid stimulation. |
Tissue Location | Expressed in kidney, heart, brain and placenta. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
References
Spangenberg C.,et al.Genomics 48:178-185(1998).
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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