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HRH2 / Histamine H2 Receptor Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P25021 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40kDa |
| Dilution | IHC-P (38 µg/ml) |
| Gene ID | 3274 |
|---|---|
| Other Names | Histamine H2 receptor, H2R, HH2R, Gastric receptor I, HRH2 |
| Target/Specificity | Human HRH2 / Histamine H2 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | HRH2 / Histamine H2 Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HRH2 |
|---|---|
| Function | The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
References
Gantz I.,et al.Biochem. Biophys. Res. Commun. 178:1386-1392(1991).
Nishi T.,et al.Biochem. Biophys. Res. Commun. 210:616-623(1995).
Murakami H.,et al.FEBS Lett. 451:327-331(1999).
Kitano T.,et al.Mol. Biol. Evol. 21:936-944(2004).
Puhl H.L. III,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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