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ADGRV1 / GPR98 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - ADGRV1 / GPR98 Antibody (Internal) ALS10440
    Anti-GPR98 antibody ALS10440 IHC of human lung, respiratory epithelium.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8WXG9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 693kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 84059
Other Names G-protein coupled receptor 98, Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1, GPR98, KIAA0686, KIAA1943, MASS1, VLGR1
Target/Specificity Human GPR98. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Short term: +4°C. Long term: aliquot and store at -70°C.
PrecautionsADGRV1 / GPR98 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADGRV1 (HGNC:17416)
Function G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q8VHN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VHN7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8VHN7} Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHN7} Note=Localizes at the ankle region of the stereocilia. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q8VHN7}
Tissue Location Expressed at low levels in adult tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor that may have an important role in the development of the central nervous system.

References

Nikkila H.,et al.Mol. Endocrinol. 14:1351-1364(2000).
McMillan D.R.,et al.J. Biol. Chem. 277:785-792(2002).
Schmutz J.,et al.Nature 431:268-274(2004).
Nagase T.,et al.DNA Res. 8:319-327(2001).
Wiemann S.,et al.Genome Res. 11:422-435(2001).

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$ 467.50
Cat# ALS10440
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