LPAR4 / GPR23 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, FC |
---|---|
Primary Accession | Q99677 |
Reactivity | Human, Mouse, Hamster, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 42kDa |
Dilution | IHC-P (2 µg/ml) |
Gene ID | 2846 |
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Other Names | Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9, LPAR4, GPR23, LPA4, P2RY9 |
Target/Specificity | Human LPAR4 / GPR23. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | LPAR4 / GPR23 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LPAR4 |
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Synonyms | GPR23, LPA4, P2RY9 |
Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1- oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1- alkenyl-LPA. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus. |
Volume | 50 µl |
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Background
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA.
References
O'Dowd B.F.,et al.Gene 187:75-81(1997).
Bohm S.K.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
Janssens R.,et al.Biochem. Biophys. Res. Commun. 236:106-112(1997).
Kopatz S.A.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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