|Dilution||IHC-P (2-36 µg/ml)|
|Other Names||Opsin-3, Encephalopsin, Panopsin, OPN3, ECPN|
|Target/Specificity||Human OPN3 / Encephalopsin. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||Encephalopsin / OPN3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31380578, PubMed:31097585). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R- mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm|
|Tissue Location||Expressed in tracheal airway smooth muscle (at protein level) (PubMed:30284927). Expressed throughout the epidermis and dermis, predominantly in the basal layer on the facial and abdominal skin (at protein level) (PubMed:30168605). Expressed in dermal fibroblasts (at protein level) (PubMed:31380578). Expressed in melanocytes (at protein level) (PubMed:28842328, PubMed:31097585, PubMed:31730232). Expressed in keratinocytes (PubMed:28842328) Expressed in the retina (PubMed:30284927)|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in encephalic photoreception.
Blackshaw S.,et al.J. Neurosci. 19:3681-3690(1999).
Halford S.,et al.Genomics 72:203-208(2001).
Kasper G.,et al.Gene 295:27-32(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).
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