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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Encephalopsin / OPN3 Antibody (C-Terminus)   

Encephalopsin / OPN3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

  • IHC - Encephalopsin / OPN3 Antibody (C-Terminus) ALS10526
    Anti-OPN3 / Encephalopsin antibody ALS10526 IHC of human brain, neurons and glia.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H1Y3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Dilution IHC-P (5-8 µg/ml)
Additional Information
Gene ID 23596
Other Names Opsin-3, Encephalopsin, Panopsin, OPN3, ECPN
Target/Specificity Human OPN3 / Encephalopsin. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsEncephalopsin / OPN3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPN3
Synonyms ECPN
Function G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31380578, PubMed:31097585). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R- mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm
Tissue Location Expressed in tracheal airway smooth muscle (at protein level) (PubMed:30284927). Expressed throughout the epidermis and dermis, predominantly in the basal layer on the facial and abdominal skin (at protein level) (PubMed:30168605). Expressed in dermal fibroblasts (at protein level) (PubMed:31380578). Expressed in melanocytes (at protein level) (PubMed:28842328, PubMed:31097585, PubMed:31730232). Expressed in keratinocytes (PubMed:28842328) Expressed in the retina (PubMed:30284927)
Volume 50 µl
Research Areas
Citations (0)

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May play a role in encephalic photoreception.


Blackshaw S.,et al.J. Neurosci. 19:3681-3690(1999).
Halford S.,et al.Genomics 72:203-208(2001).
Kasper G.,et al.Gene 295:27-32(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 467.50
Cat# ALS10526
Availability: 5 days
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