MRGD / MRGPRD Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q8TDS7 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 36kDa |
Dilution | IHC-P (17 µg/ml) |
Gene ID | 116512 |
---|---|
Other Names | Mas-related G-protein coupled receptor member D, Beta-alanine receptor, G-protein coupled receptor TGR7, MRGPRD, MRGD |
Target/Specificity | Human MRGPRD. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | MRGD / MRGPRD Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MRGPRD |
---|---|
Synonyms | MRGD |
Function | May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i). |
Cellular Location | Cell membrane; Multi-pass membrane protein Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine |
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Background
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
References
Zylka M.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
Shinohara T.,et al.J. Biol. Chem. 279:23559-23564(2004).
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
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