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FZD8 / Frizzled 8 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9H461 |
| Reactivity | Human, Mouse, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73kDa |
| Dilution | IHC-P (30 µg/ml) |
| Gene ID | 8325 |
|---|---|
| Other Names | Frizzled-8, Fz-8, hFz8, FZD8 |
| Target/Specificity | Human FZD8 / Frizzled 8. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | FZD8 / Frizzled 8 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FZD8 |
|---|---|
| Function | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. |
| Cellular Location | Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus. |
| Tissue Location | Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
References
Saitoh T.,et al.Int. J. Oncol. 18:991-996(2001).
Deloukas P.,et al.Nature 429:375-381(2004).
Semenov M.V.,et al.Curr. Biol. 11:951-961(2001).
Li X.,et al.Protein Sci. 15:2149-2158(2006).
Hao H.X.,et al.Nature 485:195-200(2012).
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