HTR7 / 5HT7 Receptor Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IHC-P |
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Primary Accession | P34969 |
Reactivity | Human, Monkey, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 54kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 3363 |
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Other Names | 5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7, HTR7 |
Target/Specificity | Human 5HT7 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LTBR (50%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | HTR7 / 5HT7 Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HTR7 {ECO:0000303|Ref.3, ECO:0000312|HGNC:HGNC:5302} |
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Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | [Isoform A]: Predominant isoform in spleen, caudate and hippocampus. [Isoform D]: Minor isoform in terms of expression. |
Volume | 50 µl |

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Provided below are standard protocols that you may find useful for product applications.
Background
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
References
Heidmann D.E.A.,et al.J. Neurochem. 68:1372-1381(1997).
Bard J.A.,et al.J. Biol. Chem. 268:23422-23426(1993).
King M.M.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).

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