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GRM2 / MGLUR2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q14416 |
| Reactivity | Human, Rabbit, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 96kDa |
| Dilution | IHC-P (10-20 µg/ml) |
| Gene ID | 2912 |
|---|---|
| Other Names | Metabotropic glutamate receptor 2, mGluR2, GRM2, GPRC1B, MGLUR2 |
| Target/Specificity | Human GRM2 / MGLUR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM3 (53%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GRM2 / MGLUR2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRM2 (HGNC:4594) |
|---|---|
| Synonyms | GPRC1B, MGLUR2 |
| Function | Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite |
| Tissue Location | Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
References
Flor P.J.,et al.Eur. J. Neurosci. 7:622-629(1995).
Yasuyuki F.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Bonner T.I.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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