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NEK9 Antibody (Kinase Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q8TD19 |
| Reactivity | Human, Mouse, Rabbit, Monkey, Pig, Chicken, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 107kDa |
| Dilution | IHC-P (4 µg/ml) |
| Gene ID | 91754 |
|---|---|
| Other Names | Serine/threonine-protein kinase Nek9, 2.7.11.1, Nercc1 kinase, Never in mitosis A-related kinase 9, NimA-related protein kinase 9, NimA-related kinase 8, Nek8, NEK9, KIAA1995, NEK8, NERCC |
| Target/Specificity | Human NEK9. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | NEK9 Antibody (Kinase Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEK9 {ECO:0000303|PubMed:12840024, ECO:0000312|HGNC:HGNC:18591} |
|---|---|
| Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
References
Holland P.M.,et al.J. Biol. Chem. 277:16229-16240(2002).
Roig J.,et al.Genes Dev. 16:1640-1658(2002).
Ohara O.,et al.DNA Res. 9:47-57(2002).
Heilig R.,et al.Nature 421:601-607(2003).
Belham C.,et al.J. Biol. Chem. 278:34897-34909(2003).
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